Chemical synthesis of cellulose and cello-oligomers using a hydrolysis enzyme as a catalyst

Shiro Kobayashi, Shin ichiro Shoda

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Regio- and stereo-selective synthesis of polysaccharides and oligosaccharides has been achieved by using glycosyl fluorides as substrates for cellulases. This methodology has successfully been applied to the first synthesis of cellulose via a non-biosynthetic pathway as well as to a selective preparation of cello-oligosaccharides and unnatural oligosaccharides. Using the enzymatic polymerization, it is possible to control the relative direction (parallel or anti-parallel) of each glucan chain in the synthetic cellulose in vitro. Based on these results, a new concept of 'allos-selectivity' in polymer synthesis has been proposed.

Original languageEnglish
Pages (from-to)373-379
Number of pages7
JournalInternational Journal of Biological Macromolecules
Volume17
Issue number6
DOIs
Publication statusPublished - 1995

Keywords

  • cellulase
  • cellulose I
  • enzymatic polymerization

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • Energy(all)

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