Chemical structures of amphidinols 5 and 6 isolated from marine dinoflagellate Amphidinium klebsii and their cholesterol-dependent membrane disruption

Gopal K. Paul, Nobuaki Matsumori, Keiichi Konoki, Michio Murata, Kazuo Tachibana

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)

Abstract

A series of polyhydroxy-polyene compounds were isolated from the cultured dinoflagellate Amphidinium klebsii as well as from its surrounding media. Amphidinol 5 (AM 5) and 6 (AM 6) were found to be potent antifungal and hemolytic agents. Their permeabilizing activity towards phospholipid liposomes was markedly enhanced by the presence of cholesterol within the bilayer, indicating that the mechanism of action involved interaction with membranal cholesterol.

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalJournal of Marine Biotechnology
Volume5
Issue number2-3
Publication statusPublished - 1997 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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