A series of polyhydroxy-polyene compounds were isolated from the cultured dinoflagellate Amphidinium klebsii as well as from its surrounding media. Amphidinol 5 (AM 5) and 6 (AM 6) were found to be potent antifungal and hemolytic agents. Their permeabilizing activity towards phospholipid liposomes was markedly enhanced by the presence of cholesterol within the bilayer, indicating that the mechanism of action involved interaction with membranal cholesterol.
|Number of pages||5|
|Journal||Journal of Marine Biotechnology|
|Publication status||Published - 1997 Dec 1|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)