Chemical Reactivities and Physical Effects in Comparison between Tocopherols and Tocotrienols: Physiological Significance and Prospects as Antioxidants

Yasukazu Yoshida, Yoshiro Saito, Leslie Sargent Jones, Yasushi Shigeri

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)

Abstract

Vitamin E is a generic term for all tocopherol and tocotrienol derivatives. The most abundant and active form of vitamin E isoforms in vivo is α-tocopherol, but recently the roles of other forms of vitamin E have received renewed attention. In this review, we summarize the differences among α-, β-, γ-, δ-tocopherols and tocotrienols specifically regarding the following points; (i) their radical-scavenging efficacies and chemical reactivity with metal ions in solution, (ii) their physical effects at the liposomal membrane interior, and (iii) their protective effects against cell toxicity. Moreover, the physiological significance and future prospects for using vitamin E, especially tocotrienols, for the prevention and treatment of disease are discussed.

Original languageEnglish
Pages (from-to)439-445
Number of pages7
JournalJournal of Bioscience and Bioengineering
Volume104
Issue number6
DOIs
Publication statusPublished - 2007 Dec 1
Externally publishedYes

Keywords

  • antioxidant
  • free radical
  • lipid peroxidation
  • tocopherol
  • tocotrienol

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Fingerprint

Dive into the research topics of 'Chemical Reactivities and Physical Effects in Comparison between Tocopherols and Tocotrienols: Physiological Significance and Prospects as Antioxidants'. Together they form a unique fingerprint.

Cite this