Chemical modification of pseurotin A: One-pot synthesis of synerazol and pseurotin E and determination of absolute stereochemistry of pseurotin E

Minoru Ishikawa, Tomohisa Ninomiya

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Two natural products, synerazol and pseurotin E, were synthesized from the natural product pseurotin A in 58% and 57% yields, respectively in one-pot procedures. This work also establishes the absolute stereochemistry of pseurotin E.

Original languageEnglish
Pages (from-to)692-695
Number of pages4
JournalJournal of Antibiotics
Volume61
Issue number11
DOIs
Publication statusPublished - 2008 Nov 1
Externally publishedYes

Keywords

  • Absolute stereochemistry
  • Chemical modification
  • Pseurotin A
  • Pseurotin E
  • Synerazol

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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