Chemical modification of carbon nanotube based bio-nanosensor by plasma activation

Takamichi Hirata, Shoji Amiya, Masahiro Akiya, Osamu Takei, Takafumi Sakai, Takahisa Nakamura, Junko Kawamura-Tsuzuku, Tadashi Yamamoto, Rikizo Hatakeyama

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Chemical modification with plasma ion irradiation (plasma activation) is demonstrated on a bio-nanosensor based on poly(ethylene glycol)-grafted single-walled carbon nanotubes (PEG-SWNTs). By X-ray photoelectron spectroscopy (XPS) analysis, peaks that correspond to CO and COOH radicals are observed. In addition, the evaluation of the characteristic responses of the bio-nanosensor using a bovine serum albumin (BSA) antigen or oligonucleotide reveals an increase in impedance due to an antigen-antibody reaction or oligonucleotide hybridization. From these results, the bio-nanosensor is found to react with a short response time (60 s).

Original languageEnglish
Pages (from-to)2068-2071
Number of pages4
JournalJapanese journal of applied physics
Issue number4 PART 1
Publication statusPublished - 2008 Apr 18
Externally publishedYes


  • Antigen-antibody reaction
  • Bio-nanosensor
  • Bovine serum albumin
  • Hybridization
  • Oligonucleotide
  • Plasma activation

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)


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