Chemical degradation of disease-related proteins: Discovery and challenge for drug discovery

Research output: Contribution to journalArticlepeer-review

Abstract

New therapeutic modalities are needed to address the problem of pathological but undruggable proteins. One emerging technology is small molecules that shorten lifespan of disease-related proteins. This article reviews induction of proteasomal degradation of the target proteins by hybrid small molecules composed of a ubiquitin ligase ligand coupled to a ligand for the target protein. This article also describes recent efforts towards undruggable proteins such as substrate binding proteins and aggregation-prone proteins, and the challenges for drug discovery.

Original languageEnglish
Pages (from-to)229-239
Number of pages11
JournalDrug Delivery System
Volume35
Issue number3
DOIs
Publication statusPublished - 2020

Keywords

  • Chemical protein degradation
  • Inhibitor of apoptosis protein
  • Neurodegenerative disorders
  • PROTACs
  • SNIPERs

ASJC Scopus subject areas

  • Pharmaceutical Science

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