Chemical characterization of the oligosaccharides in Bactrian camel (Camelus bactrianus) milk and colostrum

K. Fukuda, A. Yamamoto, K. Ganzorig, J. Khuukhenbaatar, A. Senda, T. Saito, T. Urashima

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Abstract

Bactrian camel milk and colostrum are commonly used as foods in Mongolia, whose people believe that these products promote human health. It has been hypothesized that milk oligosaccharides are biologically significant components of human milk, acting as receptor analogs that inhibit the attachment of pathogenic microorganisms to the colonic mucosa, and as prebiotics, which stimulate the growth of bifidobacteria within the infant colon. To evaluate their biological significance, we studied the oligosaccharides present in samples of Bactrian camel milk and colostrum. Using 1H-nuclear magnetic resonance spectroscopy, we identified and characterized the following oligosaccharides of camel colostrum: Gal(β1-4)[Fuc(α1-3)]Glc (3-fucosyllactose), Gal(β1-3)Gal(β1-4)Glc (3′-galactosyllactose), Gal(β1-6)Gal(β1-4)Glc (6′-galactosyllactose), Neu5Ac(α2-3)Gal(β1-4)Glc (3′-sialyllactose), Neu5Ac(α2-6)Gal(β1-4)Glc (6′-sialyllactose), Neu5Ac(α2-3)Gal(β1-3)Gal(β1-4)Glc (sialyl-3′-galactosyllactose), Neu5Ac(α2-6)Gal(β1-4)GlcNAc(β1-3)Gal(β1-4)Glc (sialyllacto-N-tetraose c), Neu5Ac(α2-3)Gal(β1-3)[Gal(β1-4)GlcNAc(β1-6)]Gal(β1-4)Glc (sialyllacto-N-novopentaose a), Gal(β1-3)[Neu5Ac(α2-6)Gal(β1-4)GlcNAc(β1-6)]Gal(β1-4)Glc (sialyllacto-N-novopentaose b); and Neu5Ac(α2-6)Gal(β1-4)GlcNAc(β1-3)[Gal(β1-4)GlcNAc(β1-6)]Gal(β1-4)Glc (monosialyllacto-N-neohexaose). The oligosaccharides in the mature camel milk were characterized as 3′-galactosyllactose, Gal(β1-3)[Gal(β1-4)GlcNAc(β1-6)]Gal(β1-4)Glc (lacto-N-novopentaose I), and 3′-sialyllactose.

Original languageEnglish
Pages (from-to)5572-5587
Number of pages16
JournalJournal of Dairy Science
Volume93
Issue number12
DOIs
Publication statusPublished - 2010 Dec

Keywords

  • Bactrian camel
  • Colostrum
  • Milk oligosaccharide
  • Sialyl oligosaccharide

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Genetics

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    Fukuda, K., Yamamoto, A., Ganzorig, K., Khuukhenbaatar, J., Senda, A., Saito, T., & Urashima, T. (2010). Chemical characterization of the oligosaccharides in Bactrian camel (Camelus bactrianus) milk and colostrum. Journal of Dairy Science, 93(12), 5572-5587. https://doi.org/10.3168/jds.2010-3151