Chemical braking exhibited by ethynylhelicene (M)-nonamer in solution: Competitive reaction system of self-catalysis to form double-helix and approach towards equilibrium to form random-coil

Tsukasa Sawato; Atsushi Yagi; Mieko Arisawa; Masahiko Yamaguchi

doi:10.1016/j.tet.2017.03.083

Chemical braking exhibited by ethynylhelicene (M)-nonamer in solution: Competitive reaction system of self-catalysis to form double-helix and approach towards equilibrium to form random-coil

Tsukasa Sawato, Atsushi Yagi, Mieko Arisawa, Masahiko Yamaguchi

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Chemical braking occurs in a dilute solution during a structural change of ethynylhelicene (M)-nonamer from the metastable double-helix state to the random-coil state, being at equilibrium, where the reaction is initially rapid and then substantially retard. The chemical braking is derived from the competitive chemical reaction system in dilute solution: An energetically uphill self-catalytic reaction to form double-helix and the downhill reaction to form the random-coil.

Original language	English
Pages (from-to)	2801-2805
Number of pages	5
Journal	Tetrahedron
Volume	73
Issue number	19
DOIs	https://doi.org/10.1016/j.tet.2017.03.083
Publication status	Published - 2017

Keywords

Chemical braking
Competitive reaction
Helicene
Metastable
Self-catalysis

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2017.03.083

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Chemical braking exhibited by ethynylhelicene (M)-nonamer in solution : Competitive reaction system of self-catalysis to form double-helix and approach towards equilibrium to form random-coil. / Sawato, Tsukasa; Yagi, Atsushi; Arisawa, Mieko; Yamaguchi, Masahiko.

In: Tetrahedron, Vol. 73, No. 19, 2017, p. 2801-2805.

Research output: Contribution to journal › Article › peer-review

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abstract = "Chemical braking occurs in a dilute solution during a structural change of ethynylhelicene (M)-nonamer from the metastable double-helix state to the random-coil state, being at equilibrium, where the reaction is initially rapid and then substantially retard. The chemical braking is derived from the competitive chemical reaction system in dilute solution: An energetically uphill self-catalytic reaction to form double-helix and the downhill reaction to form the random-coil.",

keywords = "Chemical braking, Competitive reaction, Helicene, Metastable, Self-catalysis",

author = "Tsukasa Sawato and Atsushi Yagi and Mieko Arisawa and Masahiko Yamaguchi",

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AU - Yagi, Atsushi

AU - Arisawa, Mieko

AU - Yamaguchi, Masahiko

N1 - Funding Information: This work was financial supported by Grant-in-Aid for Scientific Research (No. 21229001) from Japan Society for the Promotion of Science (JSPS) and the Uehara Memorial Foundation. M. A. expresses her appreciation to the financial supports from JSPS KAKENHI Grant Number JP15H00911. Publisher Copyright: © 2017 Elsevier Ltd

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KW - Self-catalysis

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Chemical braking exhibited by ethynylhelicene (M)-nonamer in solution: Competitive reaction system of self-catalysis to form double-helix and approach towards equilibrium to form random-coil

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Keywords

ASJC Scopus subject areas

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