Chemical and etiological studies on tetrodotoxin and its analogs

Takeshi Yasumoto, Mari Yamashita

Research output: Contribution to journalReview articlepeer-review

71 Citations (Scopus)

Abstract

The marked fluctuation of tetrodotoxin (TTX) contents in pufferfish led us to suspect the exogenous origin of the toxin. Based on a food chain hypothesis, various marine biota were tested for TTX with a fluorometric tetrodotoxin analyzer. Consequently, bacteria were found to be the genetic origin of TT. The survey also revealed the occurrence of new TTX analogs in pufferfish, newts and a frog. Those analogs were isolated and their chemical structures were determined. The analogs provided valuable information on biosynthetic as well as metabolic pathways of TTX and on structure-activity relationship.

Original languageEnglish
Pages (from-to)81-90
Number of pages10
JournalJournal of Toxicology - Toxin Reviews
Volume15
Issue number2
DOIs
Publication statusPublished - 1996 Jan 1

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Fingerprint

Dive into the research topics of 'Chemical and etiological studies on tetrodotoxin and its analogs'. Together they form a unique fingerprint.

Cite this