Chemerin analog regulates energy metabolism in sheep

Yutaka Suzuki, Sang Houn Song, Katsuyoshi Sato, Kyoung Ha So, Astrid Ardiyanti, Shun Kitayama, Yeon Hee Hong, Sung Dae Lee, Ki Choon Choi, Akihiko Hagino, Kazuo Katoh, Sang Gun Roh

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Accumulating data suggest a relationship between chemerin and energy metabolism. Our group previously described gene cloning, expression analysis and the regulatory mechanism of chemerin and its own receptor in mice and cattle. The objective of the present study was to investigate the physiological effect of chemerin on endocrine changes and energy metabolism in sheep using a biologically stable chemerin analog. The chemerin analog was intravenously administrated (100 or 500μg/head) to sheep, and plasma insulin and metabolites (glucose, nonesterified fatty acids (NEFA), triglyceride, total cholesterol and high-density lipoprotein (HDL) cholesterol) were analyzed. The chemerin analog dramatically increased the insulin levels, and glucose levels were decreased. NEFA levels were slightly decreased at 20min but then increased gradually from 60 to 180min after analog administration. In addition, injection of the chemerin analog immediately increased triglyceride and total cholesterol but not HDL levels. These results suggested that chemerin analog regulated insulin secretion related to glucose metabolism and the release of triglycerides in sheep in vivo. This study provides new information about endocrine and metabolic changes in response to chemerin in sheep.

Original languageEnglish
Pages (from-to)263-267
Number of pages5
JournalAnimal Science Journal
Volume83
Issue number3
DOIs
Publication statusPublished - 2012 Mar

Keywords

  • Chemerin analog
  • Energy metabolism
  • Insulin secretion
  • Sheep
  • Triglyceride release

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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