Characterization of variant creutzfeldt-jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes

Atsuko Takeuchi, Atsushi Kobayashi, James W. Ironside, Shirou Mohri, Tetsuyuki Kitamoto

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Background: Secondary vCJD infection may occur in all human PRNP genotypes, but its clinicopathological and biochemical phenotype is uncertain. Results: The biochemical characteristics and transmission properties of the newly generated vCJD prions are not affected by the host PRNP genotypes. Conclusion: Secondary vCJD infection can be adequately diagnosed by biochemical analysis and experimental transmission. Significance: Effective means to identify secondary vCJD infection are presented.

Original languageEnglish
Pages (from-to)21659-21666
Number of pages8
JournalJournal of Biological Chemistry
Volume288
Issue number30
DOIs
Publication statusPublished - 2013 Jul 26

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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