Characterization of variant creutzfeldt-jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes

Atsuko Takeuchi; Atsushi Kobayashi; James W. Ironside; Shirou Mohri; Tetsuyuki Kitamoto

doi:10.1074/jbc.M113.470328

Characterization of variant creutzfeldt-jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes

Atsuko Takeuchi, Atsushi Kobayashi, James W. Ironside, Shirou Mohri, Tetsuyuki Kitamoto

MED - United Centers for Advanced Research and Translational Medicine (ART)

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Background: Secondary vCJD infection may occur in all human PRNP genotypes, but its clinicopathological and biochemical phenotype is uncertain. Results: The biochemical characteristics and transmission properties of the newly generated vCJD prions are not affected by the host PRNP genotypes. Conclusion: Secondary vCJD infection can be adequately diagnosed by biochemical analysis and experimental transmission. Significance: Effective means to identify secondary vCJD infection are presented.

Original language	English
Pages (from-to)	21659-21666
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	288
Issue number	30
DOIs	https://doi.org/10.1074/jbc.M113.470328
Publication status	Published - 2013 Jul 26

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.470328

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Characterization of variant creutzfeldt-jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes. / Takeuchi, Atsuko; Kobayashi, Atsushi; Ironside, James W.; Mohri, Shirou; Kitamoto, Tetsuyuki.

In: Journal of Biological Chemistry, Vol. 288, No. 30, 26.07.2013, p. 21659-21666.

Research output: Contribution to journal › Article › peer-review

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AU - Mohri, Shirou

AU - Kitamoto, Tetsuyuki

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N2 - Background: Secondary vCJD infection may occur in all human PRNP genotypes, but its clinicopathological and biochemical phenotype is uncertain. Results: The biochemical characteristics and transmission properties of the newly generated vCJD prions are not affected by the host PRNP genotypes. Conclusion: Secondary vCJD infection can be adequately diagnosed by biochemical analysis and experimental transmission. Significance: Effective means to identify secondary vCJD infection are presented.

AB - Background: Secondary vCJD infection may occur in all human PRNP genotypes, but its clinicopathological and biochemical phenotype is uncertain. Results: The biochemical characteristics and transmission properties of the newly generated vCJD prions are not affected by the host PRNP genotypes. Conclusion: Secondary vCJD infection can be adequately diagnosed by biochemical analysis and experimental transmission. Significance: Effective means to identify secondary vCJD infection are presented.

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Characterization of variant creutzfeldt-jakob disease prions in prion protein-humanized mice carrying distinct codon 129 genotypes

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