Characterization of two novel sialyl N-acetyllactosaminyl nucleotides separated from ovine colostrum

Masashi Sasaki, Tadashi Nakamura, Kentaro Hirayama, Kenji Fukuda, Tadao Saito, Tadasu Urashima, Sadaki Asakuma

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The milk/colostrum of some mammalian species is known to contain sugar nucleotides including uridine diphosphate (UDP) oligosaccharides in addition to lactose and milk oligosaccharides, but the detailed structures of these UDP oligosaccharides have not so far been clarified. In this study we isolated two UDP-sialyl N-acetyllactosamines from ovine colostrum and characterized them using 1H-NMR and MALDI-TOFMS spectroscopies. Their structures were found to be Neu5Gc(α2–3)Gal(β1–4)GlcNAcα1-UDP and Neu5Gc(α2–6)Gal(β1–4)GlcNAcα1-UDP.

Original languageEnglish
Pages (from-to)789-796
Number of pages8
JournalGlycoconjugate Journal
Volume33
Issue number5
DOIs
Publication statusPublished - 2016 Oct 1

Keywords

  • Milk oligosaccharide
  • Milk sugar nucleotide
  • Ovine colostrum
  • UDP oligosaccharide
  • UDP sialyl N-acetyllactosamine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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