Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans, with special reference to fungicide responses

Daisuke Hagiwara, Yoshihiro Matsubayashi, Junichiro Marui, Kentaro Furukawa, Takafumi Yamashino, Kyoko Kanamaru, Masashi Kato, Keietsu Abe, Tetsuo Kobayashi, Takeshi Mizuno

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

We recently compiled a complete list of phosphorelay signal transduction components in the model filamentous fungus Aspergillus nidulans. In this study, we characterized a histidine protein kinase (designated NikA) that is found in many fungi, with special reference to responses to potent fungicides (iprodione and fludioxonil). We provided evidence that not only NikA, but also two downstream response regulators (SskA and SrrA) are crucially implicated in the mode of action of these fungicides, and also that the further downstream HogA-MAPK cascade is exaggerated abnormally (or ectopically) in hyphae by the fungicides in a manner dependent on the NikA-SskA phosphorelay.

Original languageEnglish
Pages (from-to)844-847
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume71
Issue number3
DOIs
Publication statusPublished - 2007 Mar 30

Keywords

  • Aspergillus nidulans
  • Fungicide sensitivity
  • Histidine kinase
  • Histidine-to-Aspartate (HIS-Asp) phosphorelay
  • Response regulator

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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