Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines

C. Sun, T. Yamato, Toru Furukawa, Y. Ohnishi, H. Kijima, Akira Horii

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Human pancreatic cancer is one of the most malignant diseases in the world. In order to save patients with pancreatic cancer, it is necessary to develop novel methods for treatment. For such a purpose, a series of well-characterized cancer cell lines are of great help for in vitro studies that are generally the first step in approaching the invention of novel methods for treatment. In the present study, we analyzed 15 human pancreatic cancer cell lines for genetic alterations of the K-ras, p53, p16, and SMAD4 genes, which are very frequent targets for mutation in pancreatic cancer; these cell lines are useful resources in cancer research.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalOncology reports
Volume8
Issue number1
Publication statusPublished - 2001 Jan 1

Keywords

  • K-ras
  • P16
  • P53
  • Pancreatic cancer
  • SMAD4

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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