Characterization of the Drosophila ortholog of mouse eIF-3p48/INT-6

Shukichi Miyazaki, Susan Rasmussen, Akira Imatani, Francesca Diella, David T. Sullivan, Robert Callahan

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The mouse mammary tumor virus (MMTV) has been shown to integrate frequently into INT-6 in MMTV-induced mouse mammary tumors. The INT6 gene has been highly conserved through evolution and has recently been shown to encode the p48 component of the eucaryotic translation initiation factor 3 (eIF-3) complex. We report here the isolation of the Drosophila eIF-3p48/INT-6. The gene comprises three exons within 1.8 kb of genomic DNA located at cytogenetic position 73C2 in the Drosophila genome. The 1.5 kb eIF-3p48/INT-6 RNA species encodes a protein composed of 364 amino-acid residues whose sequence is 71% similar to that of the mouse/human eIF-3/INT-6 amino-acid sequence. eIF-3p48/INT-6 RNA is expressed throughout development in Drosophila and the encoded protein is associated with the microsomal subcellular fraction.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalGene
Volume233
Issue number1-2
DOIs
Publication statusPublished - 1999 Jun 11
Externally publishedYes

Keywords

  • Eucaryotic translation initiation factor 3
  • Mammary tumor gene INT6

ASJC Scopus subject areas

  • Genetics

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