Characterization of the antiplatelet effect of aspirin at enrollment and after 2-year follow-up in a real clinical setting in Japan

Tomoyuki Ikeda, Ryoji Taniguchi, Shin Watanabe, Mitsunori Kawato, Hirokazu Kondo, Ryutaro Shirakawa, Keiichiro Yamane, Masanao Toma, Toshihiro Tamura, Kanako Takahashi, Haruyo Watanabe, Yuka Yoshikawa, Arata Tabuchi, Toru Kita, Takeshi Kimura, Hisanori Horiuchi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background: Aspirin is an antiplatelet drug widely used for the prevention of cardiovascular diseases. It has been reported that some patients who exhibit a reduced antiplatelet effect of aspirin have higher cardiovascular risk. It is still controversial whether the antiplatelet effect of aspirin diminishes after a few years of treatment. This study aimed to evaluate the antiplatelet effect of aspirin and its 2-year change in Japanese patients. Methods and Results: Collagen-induced platelet-aggregability was measured at enrollment by conventional optical aggregometer in 239 patients undergoing antiplatelet therapy with aspirin alone. Among them, 167 patients were evaluated after 2 years. Whole blood aggregability based on the screen-filtration method was also evaluated. Optical aggregometer studies showed that 27% of patients were low-responders. Multivariate analyses revealed that female sex and non-use of calcium-channel blockers were associated with low responsiveness. The antiplate-let effect of aspirin did not decrease after 2 years. Similar data were obtained with the whole blood aggregometer. Conclusions: In this Japanese patient group, 27% were low-responders to aspirin, and the antiplatelet effect of aspirin did not decrease after a 2-year interval.

Original languageEnglish
Pages (from-to)1227-1235
Number of pages9
JournalCirculation Journal
Volume74
Issue number6
DOIs
Publication statusPublished - 2010

Keywords

  • Antiplatelet therapy
  • Aspirin
  • Cardiovascular risk

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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