Characterization of retinal pigment epithelial cells and endothelial cells within a microfluidic device towards a retina on a chip

H. Kaji, S. Ito, K. Nagamine, M. Nishizawa, N. Nagai, T. Abe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

This paper reports a cell-based model of the ocular fundus within a microfluidic device. The characterization of human retinal pigment epithelial (ARPE) cells and human umbilical vein endothelial cells (HUVECs) cultured in the device was performed and found to exhibit properties found in native tissues. Also, in order to extend the culture model to an evaluation system for a drug delivery system (DDS) device, a microfluidic device was hybridized with native scleral tissues.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages742-744
Number of pages3
ISBN (Electronic)9780979806476
Publication statusPublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 2014 Oct 262014 Oct 30

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period14/10/2614/10/30

Keywords

  • Ocular fundus
  • Organ on a chip
  • Retinal pigment epithelial cell

ASJC Scopus subject areas

  • Control and Systems Engineering

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