Characterization of red-capped mangabey tetherin: Implication for the co-evolution of primates and their lentiviruses

Tomoko Kobayashi, Junko S. Takeuchi, Fengrong Ren, Kenta Matsuda, Kei Sato, Yuichi Kimura, Naoko Misawa, Rokusuke Yoshikawa, Yusuke Nakano, Eri Yamada, Hiroshi Tanaka, Vanessa M. Hirsch, Yoshio Koyanagi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Primate lentiviruses including human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency viruses (SIVs) evolved through the acquisition of antagonists against intrinsic host restriction factors, such as tetherin. It is widely accepted that HIV-1 has emerged by zoonotic transmission of SIV in chimpanzee (SIVcpz), and that SIVcpz Nef protein antagonizes chimpanzee tetherin. Although Nef of SIVcpz shares a common ancestor with that of SIVrcm, an SIV in red-capped mangabey (Cercocebus torquatus), it remains unclear whether SIVrcm Nef can antagonize tetherin of its natural host. In this study, we determine the sequence of red-capped mangabey tetherin for the first time and directly demonstrate that SIVrcm Nef is the bona fide antagonist of red-capped mangabey tetherin. These findings suggest that SIVrcm Nef is the functional ancestor of SIVcpz Nef. Moreover, molecular phylogenetic analyses reveal that tetherins of the genus Cercocebus have experienced adaptive evolution, which is presumably promoted by primate lentiviruses.

Original languageEnglish
Article number5529
JournalScientific reports
Volume4
DOIs
Publication statusPublished - 2014 Jul 2

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Characterization of red-capped mangabey tetherin: Implication for the co-evolution of primates and their lentiviruses'. Together they form a unique fingerprint.

Cite this