Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults

Keiko Nishio, Akiko Fukuhara, Yo Omata, Yoshiro Saito, Shuuhei Yamaguchi, Hisatoyo Kato, Yasukazu Yoshida, Etsuo Niki

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

There is increasing evidence indicating that free radicals and oxygenases such as cyclooxygenase (COX) and lipoxygenase (LOX) are related to the onset and development of neurodegenerative diseases. In order to prevent and/or delay these diseases, the use of radical-scavenging antioxidants and inhibitors against oxygenases has received much attention. In the present study, we examined the radical-scavenging activity and cytoprotective effects of some novel furan compounds with potent inhibitory activity against oxygenases such as COX-1, COX-2, and 5-LOX. The radical-scavenging activity was assessed by studying the bleaching of β-carotene by free radicals generated from an azo initiator. In this assay system, the rate constants for scavenging peroxyl radicals by furan S and furan L was estimated to be 2 × 104 and 3 × 104 M-1 s-1, respectively. We also investigated the cytoprotective effects of these compounds against cell death induced by several toxins. We found that the furan compounds exhibited cytoprotective effects against PC12 cell death induced by linoleic acid hydroperoxide, primary neuronal cell death induced by glutamate, and cell death induced by lipopolysaccharide. These results suggest the beneficial effects of the furan compounds against disorders related to glutamate and lipopolysaccharide.

Original languageEnglish
Pages (from-to)10332-10337
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number24
DOIs
Publication statusPublished - 2008 Dec 15
Externally publishedYes

Keywords

  • Cyclooxygenase
  • Glutamate
  • Lipopolysaccharide
  • Lipoxygenase
  • Neuronal cell death
  • Oxidative stress
  • Radical scavenging activity

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults'. Together they form a unique fingerprint.

Cite this