Characterization of monoclonal lipid A antibodies with synthetic lipid A analogues

S. Arata, J. Mashimo, N. Kasai, K. Okuda, Y. Aihara, S. Kotani, H. Takada, T. Shiba, S. Kusumoto, T. Shimamoto, N. Kusunose

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The specificity of monoclonal antibodies directed against the Salmonella minnesota R595 lipid A and the structural requirements of lipid A epitopes were studied with chemically synthesized lipid A analogues by enzyme-linked immunosorbent assay and its inhibition test. The results suggest that lipid A has specific and common epitopes, in which the specificities are derived from the chemical and conformational structures of the backbone and/or acyl groups.

Original languageEnglish
Pages (from-to)479-482
Number of pages4
JournalFEMS Microbiology Letters
Volume49
Issue number3
DOIs
Publication statusPublished - 1988 Mar

Keywords

  • Lipid A epitope
  • Monoclonal antibody
  • Synthetic lipid A analogue

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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  • Cite this

    Arata, S., Mashimo, J., Kasai, N., Okuda, K., Aihara, Y., Kotani, S., Takada, H., Shiba, T., Kusumoto, S., Shimamoto, T., & Kusunose, N. (1988). Characterization of monoclonal lipid A antibodies with synthetic lipid A analogues. FEMS Microbiology Letters, 49(3), 479-482. https://doi.org/10.1111/j.1574-6968.1988.tb02780.x