Abstract
The specificity of monoclonal antibodies directed against the Salmonella minnesota R595 lipid A and the structural requirements of lipid A epitopes were studied with chemically synthesized lipid A analogues by enzyme-linked immunosorbent assay and its inhibition test. The results suggest that lipid A has specific and common epitopes, in which the specificities are derived from the chemical and conformational structures of the backbone and/or acyl groups.
| Original language | English |
|---|---|
| Pages (from-to) | 479-482 |
| Number of pages | 4 |
| Journal | FEMS Microbiology Letters |
| Volume | 49 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1988 Mar |
Keywords
- Lipid A epitope
- Monoclonal antibody
- Synthetic lipid A analogue
ASJC Scopus subject areas
- Microbiology
- Molecular Biology
- Genetics
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Cite this
Arata, S., Mashimo, J., Kasai, N., Okuda, K., Aihara, Y., Kotani, S., Takada, H., Shiba, T., Kusumoto, S., Shimamoto, T., & Kusunose, N. (1988). Characterization of monoclonal lipid A antibodies with synthetic lipid A analogues. FEMS Microbiology Letters, 49(3), 479-482. https://doi.org/10.1111/j.1574-6968.1988.tb02780.x