Characterization of monoclonal lipid A antibodies with synthetic lipid A analogues

S. Arata; J. Mashimo; N. Kasai; K. Okuda; Y. Aihara; S. Kotani; H. Takada; T. Shiba; S. Kusumoto; T. Shimamoto; N. Kusunose

doi:10.1111/j.1574-6968.1988.tb02780.x

Characterization of monoclonal lipid A antibodies with synthetic lipid A analogues

S. Arata, J. Mashimo, N. Kasai, K. Okuda, Y. Aihara, S. Kotani, H. Takada, T. Shiba, S. Kusumoto, T. Shimamoto, N. Kusunose

DEN - Dental Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The specificity of monoclonal antibodies directed against the Salmonella minnesota R595 lipid A and the structural requirements of lipid A epitopes were studied with chemically synthesized lipid A analogues by enzyme-linked immunosorbent assay and its inhibition test. The results suggest that lipid A has specific and common epitopes, in which the specificities are derived from the chemical and conformational structures of the backbone and/or acyl groups.

Original language	English
Pages (from-to)	479-482
Number of pages	4
Journal	FEMS Microbiology Letters
Volume	49
Issue number	3
DOIs	https://doi.org/10.1111/j.1574-6968.1988.tb02780.x
Publication status	Published - 1988 Mar

Keywords

Lipid A epitope
Monoclonal antibody
Synthetic lipid A analogue

ASJC Scopus subject areas

Microbiology
Molecular Biology
Genetics

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10.1111/j.1574-6968.1988.tb02780.x

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title = "Characterization of monoclonal lipid A antibodies with synthetic lipid A analogues",

abstract = "The specificity of monoclonal antibodies directed against the Salmonella minnesota R595 lipid A and the structural requirements of lipid A epitopes were studied with chemically synthesized lipid A analogues by enzyme-linked immunosorbent assay and its inhibition test. The results suggest that lipid A has specific and common epitopes, in which the specificities are derived from the chemical and conformational structures of the backbone and/or acyl groups.",

keywords = "Lipid A epitope, Monoclonal antibody, Synthetic lipid A analogue",

author = "S. Arata and J. Mashimo and N. Kasai and K. Okuda and Y. Aihara and S. Kotani and H. Takada and T. Shiba and S. Kusumoto and T. Shimamoto and N. Kusunose",

year = "1988",

month = mar,

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language = "English",

volume = "49",

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journal = "FEMS Microbiology Letters",

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TY - JOUR

T1 - Characterization of monoclonal lipid A antibodies with synthetic lipid A analogues

AU - Arata, S.

AU - Mashimo, J.

AU - Kasai, N.

AU - Okuda, K.

AU - Aihara, Y.

AU - Kotani, S.

AU - Takada, H.

AU - Shiba, T.

AU - Kusumoto, S.

AU - Shimamoto, T.

AU - Kusunose, N.

PY - 1988/3

Y1 - 1988/3

N2 - The specificity of monoclonal antibodies directed against the Salmonella minnesota R595 lipid A and the structural requirements of lipid A epitopes were studied with chemically synthesized lipid A analogues by enzyme-linked immunosorbent assay and its inhibition test. The results suggest that lipid A has specific and common epitopes, in which the specificities are derived from the chemical and conformational structures of the backbone and/or acyl groups.

AB - The specificity of monoclonal antibodies directed against the Salmonella minnesota R595 lipid A and the structural requirements of lipid A epitopes were studied with chemically synthesized lipid A analogues by enzyme-linked immunosorbent assay and its inhibition test. The results suggest that lipid A has specific and common epitopes, in which the specificities are derived from the chemical and conformational structures of the backbone and/or acyl groups.

KW - Lipid A epitope

KW - Monoclonal antibody

KW - Synthetic lipid A analogue

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UR - http://www.scopus.com/inward/citedby.url?scp=0023855342&partnerID=8YFLogxK

U2 - 10.1111/j.1574-6968.1988.tb02780.x

DO - 10.1111/j.1574-6968.1988.tb02780.x

M3 - Article

AN - SCOPUS:0023855342

VL - 49

SP - 479

EP - 482

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

SN - 0378-1097

IS - 3

ER -

Characterization of monoclonal lipid A antibodies with synthetic lipid A analogues

Abstract

Keywords

ASJC Scopus subject areas

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