Characterization of local respiratory activity of PC12 neuronal cell by scanning electrochemical microscopy

Yuki Takii, Kimiyasu Takoh, Matsuhiko Nishizawa, Tomokazu Matsue

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Scanning electrochemical microscopy (SECM) was applied to the study of the spatial distribution of the respiratory activity in a PC12 neuronal cell. The SECM imaging of the oxygen concentration around the cells indicated that the axon of PC12 as well as its cell body consumed oxygen as the result of mitochondrial respiration. The variation in respiratory activity during NGF-induced axonal growth was monitored at the growth cone of the axon. The respiratory activity at the growth cone was found to be particularly activated by the NGF treatment.

Original languageEnglish
Pages (from-to)3381-3385
Number of pages5
JournalElectrochimica Acta
Volume48
Issue number20-22
DOIs
Publication statusPublished - 2003 Sep 30

Keywords

  • Mitochondrial distribution
  • NGF
  • PC12
  • Respiratory activity
  • Scanning electrochemical microscopy

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Electrochemistry

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