Characterization of leiomyomatoid angiomatous neuroendocrine tumour (LANT)-like tumour in the myometrium with histopathological examination

Takuma Hayashi, Tomoyuki Ichimura, Mari Kasai, Kenji Sano, Dorit Zharhary, Tanri Shiozawa, Nobuo Yaegashi, Ikuo Konishi

Research output: Contribution to journalArticlepeer-review

Abstract

Leiomyomatoid angiomatous neuroendocrine tumour (LANT) is possibly a new disease entity that was reported as a dimorphic neurosecretory tumour with a leiomyomatous vascular component; it was found in the pituitary. We describe uterine LANT-like malignant tumour in a 45-year-old woman with uterine mesenchymal tumour, diagnosed clinically as uterine leiomyoma. She underwent laparoscopic myomectomy. The tumour consisted of hyalinized vasculature, containing factor VIII-positive endothelium and α-smooth muscle actin-positive vascular smooth muscle cells, and stromal cells, expressing neuroadhesion molecules. Both vascular and stromal components diffusely expressed chromogranin A. Histopathological examinations of uterine LANT-like malignant tumour revealed the common characteristic abnormalities of malignant uterine mesenchymal tumours, i.e. leiomyosarcomas. From our research, defective expression of calponin H1 and proteasome ß9 (PSMB9)/ß1i is observed in uterine LANT-like malignant tumour similarly to immunopathological findings of uterine leiomyosarcoma. These findings meet the definition of uterine LANT-like malignant tumour, and the research findings of our clinical case suggest that LANT is a special type of neuroendocrine neoplasm and is not organ specific.

Original languageEnglish
Pages (from-to)1765-1772
Number of pages8
JournalAnticancer research
Volume37
Issue number4
DOIs
Publication statusPublished - 2017 Apr

Keywords

  • Calponin H1
  • LANT
  • Leiomyosarcoma
  • Mesenchymal tumour
  • PSMB9

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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