Characterization of cell surface antigens expressed in the HMA-1 breast cancer cell line

Noriaki Ohuchi, Yuko Harada, Takashi Masuko, Shigeo Matano, Shozo Mori

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

This report describes the characterization of an estrogen receptor-positive breast cancer cell line, HMA-1, established from a breast cancer patient, based on the expression of tumor-associated antigens (TAAs), the HLA-DR antigen, and the c-erbB-2 proto-oncogene product. In flow cytometric and immunohistochemical analyses, HMA-1 was found to express increased levels of several TAAs including MUC1, TAG-72 (sialyl Tn), Tn, T, sialyl Lea, Lex, and Ley, HMA-1 also expressed enhanced levels of the HLA-DR antigen and c-erbB-2 protein. These results indicate that HMA-1 is a unique cell line with abundant TAAs which may serve as an appropriate breast cancer cell line for application in the multidisciplinary research of breast cancer.

Original languageEnglish
Pages (from-to)244-250
Number of pages7
JournalSurgery today
Volume25
Issue number3
DOIs
Publication statusPublished - 1995 Mar

Keywords

  • MUC1 c-erbB-2 proto-oncogene
  • TAG-72
  • breast cancer cell line
  • tumor-associated antigen

ASJC Scopus subject areas

  • Surgery

Fingerprint

Dive into the research topics of 'Characterization of cell surface antigens expressed in the HMA-1 breast cancer cell line'. Together they form a unique fingerprint.

Cite this