Characterization of a titanium(IV)-porphyrin complex as a highly sensitive and selective reagent for the determination of hydrogen peroxide: A computational chemistry approach and a critical review

Kiyoko Takamura, Takatoshi Matsumoto

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The Ti-TPyP reagent, i.e. an acidic aqueous solution of the oxo[5,10,15,20-tetra(4-pyridyl)porphyrinato] titanium(IV) complex, TiO(tpyp), was developed as a highly sensitive and selective spectrophotometric reagent for determination of traces of hydrogen peroxide. Using this reagent, determination of hydrogen peroxide was performed by flow-injection analysis with a detection limit of 0.5 pmol per test. The method was actually applied to determination of several constituents of foods, human blood, and urine mediated by appropriate oxidase enzymes. The reaction specificity of the TiO(tpyp) complex for hydrogen peroxide was clarified from the viewpoint of the reaction mechanisms and molecular orbitals based on ab initio calculations. The results provided a well-grounded argument for determination of hydrogen peroxide using the Ti-TPyP reagent experimentally. This review deals with characterization of the high sensitivity and reaction specificity of the Ti-TPyP reagent for determination of hydrogen peroxide, to prove its reliability in analytical applications.

Original languageEnglish
Pages (from-to)951-961
Number of pages11
JournalAnalytical and Bioanalytical Chemistry
Volume391
Issue number3
DOIs
Publication statusPublished - 2008 Jun 1

Keywords

  • Ab initio calculation
  • Determination of HO
  • Flow-injection analysis
  • Ti-TPyP reagent

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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