TY - JOUR
T1 - Characteristics of the increase in plasma brain natriuretic peptide level in left ventricular systolic dysfunction, associated with muscular dystrophy in comparison with idiopathic dilated cardiomyopathy
AU - Demachi, Jun
AU - Kagaya, Yutaka
AU - Watanabe, Jun
AU - Sakuma, Masahito
AU - Ikeda, Jun
AU - Kakuta, Yasunori
AU - Motoyoshi, Iyoko
AU - Kohnosu, Takeshi
AU - Sakuma, Hiroaki
AU - Shimazaki, Shigeru
AU - Sakai, Hideaki
AU - Kimpara, Teiko
AU - Takahashi, Toshiaki
AU - Omura, Kiyoshi
AU - Okada, Miho
AU - Saito, Hiroshi
AU - Shirato, Kunio
PY - 2004/11
Y1 - 2004/11
N2 - To determine whether the plasma brain natriuretic peptide level increases differentially in muscular dystrophy and idiopathic dilated cardiomyopathy, we investigated the plasma brain natriuretic peptide level and echocardiographic parameters in patients with similarly low left ventricular ejection fraction. The plasma brain natriuretic peptide level was lower, and the left ventricular end-diastolic diameter was shorter in the patients with muscular dystrophy than in those with idiopathic dilated cardiomyopathy. The correlation between the plasma brain natriuretic peptide and left ventricular ejection fraction was shifted downward in the patients with muscular dystrophy compared with those with idiopathic dilated cardiomyopathy. Those between the brain natriuretic peptide and left ventricular end-diastolic diameter were superimposable, although the data from the muscular dystrophy patients were located at the shorter left ventricular end-diastolic diameter side. The plasma brain natriuretic peptide level may differentially increase in the two diseases with similar left ventricular systolic dysfunction. Differences in the left ventricular distension and in the physical activity might explain at least partially the different plasma brain natriuretic peptide levels.
AB - To determine whether the plasma brain natriuretic peptide level increases differentially in muscular dystrophy and idiopathic dilated cardiomyopathy, we investigated the plasma brain natriuretic peptide level and echocardiographic parameters in patients with similarly low left ventricular ejection fraction. The plasma brain natriuretic peptide level was lower, and the left ventricular end-diastolic diameter was shorter in the patients with muscular dystrophy than in those with idiopathic dilated cardiomyopathy. The correlation between the plasma brain natriuretic peptide and left ventricular ejection fraction was shifted downward in the patients with muscular dystrophy compared with those with idiopathic dilated cardiomyopathy. Those between the brain natriuretic peptide and left ventricular end-diastolic diameter were superimposable, although the data from the muscular dystrophy patients were located at the shorter left ventricular end-diastolic diameter side. The plasma brain natriuretic peptide level may differentially increase in the two diseases with similar left ventricular systolic dysfunction. Differences in the left ventricular distension and in the physical activity might explain at least partially the different plasma brain natriuretic peptide levels.
KW - Brain natriuretic peptide
KW - Dilated cardiomyopathy
KW - Left ventricular ejection fraction
KW - Muscular dystrophy
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U2 - 10.1016/j.nmd.2004.08.002
DO - 10.1016/j.nmd.2004.08.002
M3 - Article
C2 - 15482958
AN - SCOPUS:5144224072
VL - 14
SP - 732
EP - 739
JO - Neuromuscular Disorders
JF - Neuromuscular Disorders
SN - 0960-8966
IS - 11
ER -