Characteristics of surface behavior and osteoinductivity of biomimetic ceramic scaffold

J. Tazaki, M. Murata, T. Akazawa, M. Yamamoto, K. Ito, J. Hino, Y. Minamida, H. Nagayasu, M. Arisue, T. Shibata, Y. Tabata

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We previously reported functionally graded hydroxyapatite (fg-HAp) with the characteristics of blood permeability into the bulk and osteoinduction by adding low dose of bone morphogenetic protein-2 (BMP-2). In this study, we evaluated the bioactivity of the obtained dense HAp bodies in a simulated body fluid (SBF) and the osteoinductive activity with or without SBF treatment in vivo. The fg-HAp·SBF was prepared by immersing the fg-HAp in the SBF solution at 14 days and the surface structure was observed by SEM. The fg-HAp·SBF showed fine bone-like crystal on the surface of the HAp. Ectopic bone formation occurred in the fg-HAp/BMP-2 (1.0, 0.5μg) system at 3 weeks, while only in the fg-HAp·SBF/BMP-2 (1.0μg), bone induction was found. The histological finding showed body fluid permeation into the fg-HAp·SBF bulk and bone formation were obserbed.

Original languageEnglish
Title of host publicationBioceramics 24
PublisherTrans Tech Publications Ltd
Pages50-54
Number of pages5
Edition1
ISBN (Print)9783037855171
DOIs
Publication statusPublished - 2013 Jan 1
Externally publishedYes
Event24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012 - Fukuoka, Japan
Duration: 2012 Oct 212012 Oct 24

Publication series

NameKey Engineering Materials
Number1
Volume529-530
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Other

Other24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
CountryJapan
CityFukuoka
Period12/10/2112/10/24

Keywords

  • Biomimetic
  • Ceramic scaffold
  • Osteoinductivity
  • Surface behavior

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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