TY - JOUR
T1 - Characteristics of novel Ti–10Mo-xCu alloy by powder metallurgy for potential biomedical implant applications
AU - Xu, Wei
AU - Hou, Chenjin
AU - Mao, Yuxuan
AU - Yang, Lei
AU - Tamaddon, Maryam
AU - Zhang, Jianliang
AU - Qu, Xuanhui
AU - Liu, Chaozong
AU - Su, Bo
AU - Lu, Xin
N1 - Funding Information:
This research work is supported by the National Natural Science Foundation of China ( 51922004 , 51874037 , 51672184 ), State Key Lab of Advanced Metals and Materials, University of Science and Technology Beijing ( 2019-Z14 ) and Fundamental Research Funds for the Central Universities ( FRF-TP-19005C1Z ). Chaozong Liu acknowledges the support from the European Commission via the H2020 MSCA RISE BAMOS programme ( 734156 ). Bo Su would like to thank financial support from the MRC ( MR/S010343/1 ) and the EU H2020 MSCA RISE Bio-TUNE programme. Wei Xu acknowledges the support from the China Scholarship Council (CSC) for a CSC Ph.D. scholarship ( 201906460106 ).
Publisher Copyright:
© 2020
PY - 2020/9
Y1 - 2020/9
N2 - When biomaterials are implanted in the human body, the surfaces of the implants become favorable sites for microbial adhesion and biofilm formation, causing peri-implant infection which frequently results in the failure of prosthetics and revision surgery. Ti–Mo alloy is one of the commonly used implant materials for load-bearing bone replacement, and the prevention of infection of Ti–Mo implants is therefore crucial. In this study, bacterial inhibitory copper (Cu) was added to Ti–Mo matrix to develop a novel Ti–Mo–Cu alloy with bacterial inhibitory property. The effects of Cu content on microstructure, tensile properties, cytocompatibility, and bacterial inhibitory ability of Ti–Mo–Cu alloy were systematically investigated. Results revealed that Ti–10Mo–1Cu alloy consisted of α and β phases, while there were a few Ti2Cu intermetallic compounds existed for Ti–10Mo–3Cu and Ti–10Mo–5Cu alloys, in addition to α and β phases. The tensile strength of Ti–10Mo-xCu alloy increased with Cu content while elongation decreased. Ti–10Mo–3Cu alloy exhibited an optimal tensile strength of 1098.1 MPa and elongation of 5.2%. Cytocompatibility study indicated that none of the Ti–10Mo-xCu alloys had a negative effect on MC3T3-E1 cell proliferation. Bacterial inhibitory rates against S. aureus and E. coli increased with the increase in Cu content of Ti–10Mo-xCu alloy, within the ranges of 20–60% and 15–50%, respectively. Taken together, this study suggests that Ti–10Mo–3Cu alloy with high strength, acceptable elongation, excellent cytocompatibility, and the bacterial inhibitory property is a promising candidate for biomedical implant applications.
AB - When biomaterials are implanted in the human body, the surfaces of the implants become favorable sites for microbial adhesion and biofilm formation, causing peri-implant infection which frequently results in the failure of prosthetics and revision surgery. Ti–Mo alloy is one of the commonly used implant materials for load-bearing bone replacement, and the prevention of infection of Ti–Mo implants is therefore crucial. In this study, bacterial inhibitory copper (Cu) was added to Ti–Mo matrix to develop a novel Ti–Mo–Cu alloy with bacterial inhibitory property. The effects of Cu content on microstructure, tensile properties, cytocompatibility, and bacterial inhibitory ability of Ti–Mo–Cu alloy were systematically investigated. Results revealed that Ti–10Mo–1Cu alloy consisted of α and β phases, while there were a few Ti2Cu intermetallic compounds existed for Ti–10Mo–3Cu and Ti–10Mo–5Cu alloys, in addition to α and β phases. The tensile strength of Ti–10Mo-xCu alloy increased with Cu content while elongation decreased. Ti–10Mo–3Cu alloy exhibited an optimal tensile strength of 1098.1 MPa and elongation of 5.2%. Cytocompatibility study indicated that none of the Ti–10Mo-xCu alloys had a negative effect on MC3T3-E1 cell proliferation. Bacterial inhibitory rates against S. aureus and E. coli increased with the increase in Cu content of Ti–10Mo-xCu alloy, within the ranges of 20–60% and 15–50%, respectively. Taken together, this study suggests that Ti–10Mo–3Cu alloy with high strength, acceptable elongation, excellent cytocompatibility, and the bacterial inhibitory property is a promising candidate for biomedical implant applications.
KW - Bacterial inhibitory property
KW - Cytocompatibility
KW - Mechanical properties
KW - Microstructure
KW - Ti-10Mo-xCu alloy
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U2 - 10.1016/j.bioactmat.2020.04.012
DO - 10.1016/j.bioactmat.2020.04.012
M3 - Article
AN - SCOPUS:85084252955
VL - 5
SP - 659
EP - 666
JO - Bioactive Materials
JF - Bioactive Materials
SN - 2452-199X
IS - 3
ER -