Characteristics and 1-year prognosis of medically treated patients with chronic heart failure in Japan: Chronic heart failure analysis registry in Tohoku district (CHART)

Yoshito Koseki, Jun Watanabe, Tsuyoshi Shinozaki, Masahito Sakuma, Tatsuya Komaru, Mitsumasa Fukuchi, Masahito Miura, Akihiko Karibe, Yuji Kon-no, Hirotaka Numaguchi, Mototsugu Ninomiya, Yutaka Kagaya, Kunio Shirato, J. Kikuchi, S. Oyama, K. Tamaki, E. Nozaki, H. Hozawa, Y. Yamamoto, T. NozakiS. Suzuki, Y. Onodera, M. Nakagawa, N. Hoshi, A. Nakamura, S. Sato, H. Kinoshita, M. Funakoshi, M. Hayashi, H. Watanabe, N. Sekiguchi, M. Takeuchi, M. Chida, M. Ohe, M. Komatu, M. Sugi, S. Namiuchi, N. Uesugi, Y. Sekiguchi, N. Shiba, S. Horiguchi, H. Shioiri, S. Kitaoka, H. Kyono, K. Inoue, K. Sakurai, T. Watanabe, M. Kanazawa, A. Kato, A. Sugimura, T. Tanikawa, T. Mimata, N. Ishide, H. Oda, T. Hiramoto, T. Nunokawa, N. Itoh, M. Kuroha

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The study was designed to characterize patients with chronic heart failure (CHF) in Japan in terms of the etiologies and prognosis. CHF was defined by ejection fraction (EF ≥50%), left ventricular diastolic dimension (LVDD ≥55 mm) or a past history of congestive heart failure. Among the 721 recruited patients, the most frequent etiology for CHF was dilated cardiomyopathy (DCM) in patients aged less than 59 years, and valvular heart disease (VHD) in those aged 70 years or more. The 1-year crude mortality was 8% overall and 12% in patients with myocardial infarction (MI). Sudden death accounted for 40% of the total deaths among all patients, and 60% in patients with MI. Multivariate logistic regression analysis showed that brain natriuretic peptide (BNP) was a consistent prognostic marker in CHF patients with a variety of etiologies. Total death and hospitalization because of heart failure were significantly less frequent in patients with BNP less than 100 pg/ml. In conclusion, the etiologies of Japanese CHF appear to be more diverse than those of other Western countries, but BNP is an excellent prognostic marker despite the etiological diversity. Sudden, unexpected death in CHF patients is also a serious problem in Japan. A nation-wide epidemiologic study should be done to characterize Japanese CHF.

Original languageEnglish
Pages (from-to)431-436
Number of pages6
JournalCirculation Journal
Volume67
Issue number5
DOIs
Publication statusPublished - 2003 May 1

Keywords

  • Brain natriuretic peptide
  • Ejection fraction
  • Etiology
  • Heart failure death
  • Sudden death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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