Characteristic correlations of the structure-function relationship in different glaucomatous disc types

Kazuko Omodaka, Naoko Takada, Takuhiro Yamaguchi, Hidetoshi Takahashi, Makoto Araie, Toru Nakazawa

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Purpose: To investigate the influence of the optic disc type on the overall and regional correlation between structure and function in open angle glaucoma (OAG). Methods: We divided 144 eyes of 144 patients with OAG into four groups according to Nicolela et al.’s classification of optic disc type: focal ischemic (FI), myopic glaucomatous (MY), senile sclerotic (SS), and generalized enlargement (GE). We measured the circumpapillary retinal nerve fiber layer thickness (cpRNFLT) with the 3D OCT-2000 and the mean deviation (MD) with the Humphrey Field Analyzer in each group and determined the influence of the disc type on these parameters with the Spearman rank correlation. Results: We found that cpRNFLT and MD were significantly correlated in the MY (r = 0.61, P < 0.001), GE (r = 0.62, P < 0.001), and SS groups (r = 0.52, P = 0.002), but not in the FI group (r = 0.25, P = 0.130). The region of the optic disc with the highest correlation coefficient between structure and function differed according to the disc type. Conclusions: The correlation between cpRNFLT and MD varied according to the optic disc morphology in OAG. This suggests that different disc types have characteristic regional variations in the correlation between structure and function. The disc type should therefore be considered in investigations of the correlation between structure and function in glaucoma.

Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalJapanese Journal of Ophthalmology
Issue number4
Publication statusPublished - 2015 Jul 23


  • Axonal damage
  • Glaucoma stage
  • Open angle glaucoma
  • Optic disc type
  • Optical coherence tomography

ASJC Scopus subject areas

  • Ophthalmology


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