Channelrhodopsins-Their potential in gene therapy for neurological disorders

Zhi Gang Ji, Toru Ishizuka, Hiromu Yawo

    Research output: Contribution to journalReview articlepeer-review

    9 Citations (Scopus)

    Abstract

    Recently, channelrhodopsins (ChRs) have begun to be used to manipulate the neuronal activity, since they can be targeted to specific neurons or neural circuits using genetic methods. To advance the potential applications in the investigation and treatment of neurological disorders, the following types of basic research should receive extensive financial support. The spectral and kinetic properties of ChRs should be optimized according to the application by generating variants of ChRs or exploring new rhodopsins from other species. These ChRs should be targeted to the specific types of neurons involved in the neurological disorders through a gene expression system using cell- or tissue-specific promoters/enhancers as well as gene delivery systems with modified virus vectors. The methods have to be developed to apply the genes of interest with safety and long-term effectiveness. Sophisticated opto-electrical devices should be developed. Appropriate primate animal model systems should be established to minimize the structural differences between small animals such as rodents and human beings. In this paper, we will review the current progress in the basic research concerned with the potential clinical application of ChRs and discuss the future directions of research on ChRs so that they could be applied for human welfare.

    Original languageEnglish
    Pages (from-to)6-12
    Number of pages7
    JournalNeuroscience Research
    Volume75
    Issue number1
    DOIs
    Publication statusPublished - 2013 Jan

    Keywords

    • Adeno-associated virus (AAV)
    • Age-related macular degeneration (AMD)
    • Channelrhodopsin
    • Deep brain stimulation (DBS)
    • Epilepsy
    • Gene delivery
    • Halorhodopsin
    • Neural dysfunction
    • Neurological disorders
    • Optics
    • Optogenetics
    • Parkinson disease
    • Primates
    • Retinal prosthesis
    • Retinis pigmentosa (RP)
    • Spinal cord injury (SCI)

    ASJC Scopus subject areas

    • Neuroscience(all)

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