Changes of the thromboxane A2/prostacyclin balance in the urine of patients with renal diseases analyzed by gas chromatography/selected ion monitoring

Takanori Hishinuma, Yuko Koseki, Jun Katayama, Yuriko Murai, Takao Saito, Michinao Mizugaki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The thromboxane A2/prostacyclin (TX/PGI) ratios were measured in patients with renal diseases to elucidate the relationship between the ratios and the pathological changes of the diseases. Urinary stable metabolites of thromboxane A2 and prostacyclin, 11-dehydro-thromboxane B2 and 2,3-dinor-6- keto-prostaglandin F(1α), respectively, were converted to 1-methyl ester- propylamide-9,12,15-tris-dimethylisopropylsilyl ether derivative and 1-methyl ester-6-methoxime-9,12,15-tris-dimethylisopropylsilyl ether derivative, respectively, and applied to a gas chromatography/selected ion monitoring. The TX/PGI ratios of 10 outpatients and 6 inpatients with chronic glomerulonephritis were higher than those of 13 healthy volunteers. In an inpatient with systemic lupus erythematoides, the TX/PGI ratios were gradually lowered to the normal level with the therapies. Furthermore, the ratios seemed to change in advance of the changes of the levels of urinary protein and hematuria. These observations suggested that the TX/PGI ratio was a useful index to assess the pathological condition of renal diseases and the effects of treatment. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalProstaglandins and Other Lipid Mediators
Volume60
Issue number1-3
DOIs
Publication statusPublished - 2000 Jan 1

Keywords

  • Gas chromatography/selected ion monitoring (GC/SIM)
  • Prostacyclin
  • Prostaglandin
  • Renal disease
  • Thromboxane

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

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