Changes of free fatty acids and Acyl-CoAs in rat brain hippocampal slice with tetraethylammonium-induced long-term potentiation

Qinzeng Zhang, Satoshi Yoshida, Kumiko Sakai, Jie Liu, Kohji Fukunaga

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We investigated the role of acyl-CoAs during induction and maintenance of long-term potentiation in rat brain hippocampus. Changes of acyl-CoA and free fatty acids (FFA) in hippocampus were measured during tetraethylammonium (TEA)-induced LTP. Results indicated that concentrations of acyl-CoAs and FFAs in slices were changed during TEA-induced LTP and 16:0-CoA and 18:0-CoA were increased in the early phase of stimulation, whereas free fatty acids in this phase were rather decreased. The increase of 20:4-CoA was delayed more than saturated acyl-CoAs. To examine the role of acyl-CoA in LTP of evoked transmitter release, we measured the glutamate release from hippocampal slice with the addition of acyl-CoA using glutamate electrode. Acyl-CoA (16:0-, 18:1-, and 20:P CoA) could enhance glutamate release in hippocampal slice. It is suggested that saturated acyl-CoAs may play a functional role in the early phase of LTP. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)208-212
Number of pages5
JournalBiochemical and biophysical research communications
Volume267
Issue number1
DOIs
Publication statusPublished - 2000 Jan 7

Keywords

  • Acyl-CoA
  • Free fatty acid
  • Glutamate release
  • Long-term potentiation
  • Tetraethylammonium chloride

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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