Changes in the levels of low molecular weight metabolites in the mouse cerebellum following treatment with methylmercury

Gi Wook Hwang, Jin Yong Lee, Min Seok Kim, Masayuki Sato, Tsutomu Takahashi, Akira Naganuma

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Metabolomic analysis was performed using the cerebellum of methylmercury-treated mice to elucidate the molecular mechanisms underlying methylmercury-induced cerebellar dysfunction. Methylmercury administration led to significant increases in the levels of 11 low molecular weight metab-olites and significant reductions in the levels of 29 others, including several metabolites produced by ami-no acid and purine metabolism. Non-significant decreases in metabolites involved in the TCA cycle and in glutathione metabolism were also observed. in glutathione metabolism were also observed.

Original languageEnglish
Pages (from-to)703-706
Number of pages4
JournalJournal of Toxicological Sciences
Volume38
Issue number5
DOIs
Publication statusPublished - 2013

Keywords

  • Cerebellum
  • Metabolomics
  • Methylmercury
  • Mice

ASJC Scopus subject areas

  • Toxicology

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