Changes in temperature preferences and energy homeostasis in dystroglycan mutants

Ken Ichi Takeuchi, Yoshiro Nakano, Utako Kato, Mizuho Kaneda, Masako Aizu, Wakae Awano, Shigenobu Yonemura, Shigeki Kiyonaka, Yasuo Mori, Daisuke Yamamoto, Masato Umeda

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)

    Abstract

    Temperature affects the physiology, behavior, and evolution of organisms. We conducted mutagenesis and screens for mutants with altered temperature preference in Drosophila mehnogaster and identified a cryophilic (cold-seeking) mutant, named atsugari (atu). Reduced expression of the Drosophila ortholog of dystroglycan (DmDG) induced tolerance to cold as well as preference for the low temperature. A sustained increase in mitochondrial oxidative metabolism caused by the reduced expression of DmDG accounted for the cryophilic phenotype of the atu mutant. Although most ectothermic animals do not use metabolically produced heat to regulate body temperature, our results indicate that their thermoregulatory behavior is closely linked to rates of mitochondrial oxidative metabolism and that a mutation in a single gene can induce a sustained change in energy homeostasis and the thermal responses.

    Original languageEnglish
    Pages (from-to)1740-1743
    Number of pages4
    JournalScience
    Volume323
    Issue number5922
    DOIs
    Publication statusPublished - 2009 Mar 27

    ASJC Scopus subject areas

    • General

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