Changes in susceptibity of clinical isolates of Staphylococcus aureus to quinolones and other antibacterial agents from 1986 to 1993

Hirosi Takahashi, Satoru Shoji, Hiroaki Kikuchi, Akira Watanabe, Toshihiro Nukiwa, Yoshihiro Honda, Yutaka Tokue

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    We investigated the susceptibity to quinolones and other antimicrobacterial agents of 1,697 Staphylococcus aureus clinical isolates from the Tohoku district collected over the last eight years. The incidence of methicillin-resistant Staphylococcus aureus (MRSA) rose from 25.5% to 49.1% during the eight years. During the above period, susceptibity to ofloxacin remained at almost the same level for methicillin-susceptible Staphylococcus aureus (MSSA). On the other hand MRSA became more resistant year by year, and the MIC90 of ofloxacin against MRSA rose from 0.78 μg/ml in 1986 to 64 μg/ml in 1993. This tendency was observed very frequently among isolates from all institutions and specimens, irrespective of whether they were from in- or out-patients. In was also found that these isolates were generally resistant to quinolones other than ofloxacin.

    Original languageEnglish
    Pages (from-to)547-550
    Number of pages4
    JournalJapanese Journal of Chemotherapy
    Volume43
    Issue number5
    DOIs
    Publication statusPublished - 1995 Jan 1

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)

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