Changes in membrane potential: An early signal triggered by neurologically active phycotoxins

M. C. Louzao, M. R. Vieytes, T. Yasumoto, Mari Yamashita, L. M. Botana

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Most common phycotoxin poisoning syndromes have important neurological symptoms. However, little is known of the cellular and molecular targets of many of the phycotoxins that produce those human intoxications. We explore the effect of representative toxins on the membrane potential in human neuroblastoma cells by using a fluorimetric assay. Results presented in this study demonstrate that maitotoxin, palytoxins, brevetoxins, and ciguatoxins triggered a dose-dependent membrane depolarization. Mechanisms responsible for the toxins-induced changes in membrane potential are always related to a direct action of the compounds on membrane ion fluxes. This initial screening of the phycotoxins effect is the starting point to lately develop functional methods of detection.

Original languageEnglish
Pages (from-to)788-793
Number of pages6
JournalChemical Research in Toxicology
Volume19
Issue number6
DOIs
Publication statusPublished - 2006 Jun 1

ASJC Scopus subject areas

  • Toxicology

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