Changes in membrane potential: An early signal triggered by neurologically active phycotoxins

M. C. Louzao, M. R. Vieytes, T. Yasumoto, Mari Yamashita, L. M. Botana

    Research output: Contribution to journalArticlepeer-review

    22 Citations (Scopus)

    Abstract

    Most common phycotoxin poisoning syndromes have important neurological symptoms. However, little is known of the cellular and molecular targets of many of the phycotoxins that produce those human intoxications. We explore the effect of representative toxins on the membrane potential in human neuroblastoma cells by using a fluorimetric assay. Results presented in this study demonstrate that maitotoxin, palytoxins, brevetoxins, and ciguatoxins triggered a dose-dependent membrane depolarization. Mechanisms responsible for the toxins-induced changes in membrane potential are always related to a direct action of the compounds on membrane ion fluxes. This initial screening of the phycotoxins effect is the starting point to lately develop functional methods of detection.

    Original languageEnglish
    Pages (from-to)788-793
    Number of pages6
    JournalChemical Research in Toxicology
    Volume19
    Issue number6
    DOIs
    Publication statusPublished - 2006 Jun 1

    ASJC Scopus subject areas

    • Toxicology

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