TY - JOUR
T1 - Changes in circulating biomarkers during a single hemodialysis session
AU - Yamamoto, Tae
AU - Nascimento, Marcelo M.
AU - Hayashi, Shirley Y.
AU - Qureshi, Abdul Rashid
AU - Waniewski, Jacek
AU - Brodin, Lars Åke
AU - Anderstam, Björn
AU - Lind, Britta
AU - Riella, Miguel C.
AU - Seeberger, Astrid
AU - Lindholm, Bengt
PY - 2013/1/1
Y1 - 2013/1/1
N2 - The hemodialysis (HD) procedure induces an inflammatory response potentially contributing to cardiovascular disease. Here we investigated the acute impact of HD on circulating biomarkers. Circulating biomarkers (small solutes, middle molecular-sized peptides, and proteins) related to inflammation, oxidative stress, and vascular calcification (VC) were measured before and after a single session of HD in 45 clinically stable patients. Concentrations were corrected for ultrafiltration-induced hemoconcentration. Among vascular calcification-related biomarkers, osteoprotegerin and fetuin-A remained unchanged while fibroblast growth factor-23 (FGF23) decreased by -19%. Changes of FGF23 and changes of phosphate correlated (ρ=0.61, P<0.001). While C-reactive protein did not change, interleukin-6 (IL-6) increased by 14% and pentraxin 3 (PTX3) increased by 45%. IL-6 and PTX3 appear to be valid biomarkers of the intradialytic inflammatory response. VC-related markers were in general not affected by the single HD session; however, the observed correlation between acute changes of FGF-23 and phosphate during HD warrants further studies. Hemodialysis International
AB - The hemodialysis (HD) procedure induces an inflammatory response potentially contributing to cardiovascular disease. Here we investigated the acute impact of HD on circulating biomarkers. Circulating biomarkers (small solutes, middle molecular-sized peptides, and proteins) related to inflammation, oxidative stress, and vascular calcification (VC) were measured before and after a single session of HD in 45 clinically stable patients. Concentrations were corrected for ultrafiltration-induced hemoconcentration. Among vascular calcification-related biomarkers, osteoprotegerin and fetuin-A remained unchanged while fibroblast growth factor-23 (FGF23) decreased by -19%. Changes of FGF23 and changes of phosphate correlated (ρ=0.61, P<0.001). While C-reactive protein did not change, interleukin-6 (IL-6) increased by 14% and pentraxin 3 (PTX3) increased by 45%. IL-6 and PTX3 appear to be valid biomarkers of the intradialytic inflammatory response. VC-related markers were in general not affected by the single HD session; however, the observed correlation between acute changes of FGF-23 and phosphate during HD warrants further studies. Hemodialysis International
KW - Cardiovascular disease
KW - Hemodialysis
KW - Interleukin-6
KW - Microinflammation
KW - Pentraxin-3
KW - Vascular calcification
UR - http://www.scopus.com/inward/record.url?scp=84872648128&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872648128&partnerID=8YFLogxK
U2 - 10.1111/j.1542-4758.2012.00720.x
DO - 10.1111/j.1542-4758.2012.00720.x
M3 - Article
C2 - 22716238
AN - SCOPUS:84872648128
VL - 17
SP - 59
EP - 66
JO - Hemodialysis International
JF - Hemodialysis International
SN - 1492-7535
IS - 1
ER -
