Changes in circulating biomarkers during a single hemodialysis session

Tae Yamamoto, Marcelo M. Nascimento, Shirley Y. Hayashi, Abdul Rashid Qureshi, Jacek Waniewski, Lars Åke Brodin, Björn Anderstam, Britta Lind, Miguel C. Riella, Astrid Seeberger, Bengt Lindholm

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

The hemodialysis (HD) procedure induces an inflammatory response potentially contributing to cardiovascular disease. Here we investigated the acute impact of HD on circulating biomarkers. Circulating biomarkers (small solutes, middle molecular-sized peptides, and proteins) related to inflammation, oxidative stress, and vascular calcification (VC) were measured before and after a single session of HD in 45 clinically stable patients. Concentrations were corrected for ultrafiltration-induced hemoconcentration. Among vascular calcification-related biomarkers, osteoprotegerin and fetuin-A remained unchanged while fibroblast growth factor-23 (FGF23) decreased by -19%. Changes of FGF23 and changes of phosphate correlated (ρ=0.61, P<0.001). While C-reactive protein did not change, interleukin-6 (IL-6) increased by 14% and pentraxin 3 (PTX3) increased by 45%. IL-6 and PTX3 appear to be valid biomarkers of the intradialytic inflammatory response. VC-related markers were in general not affected by the single HD session; however, the observed correlation between acute changes of FGF-23 and phosphate during HD warrants further studies. Hemodialysis International

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalHemodialysis International
Volume17
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

Keywords

  • Cardiovascular disease
  • Hemodialysis
  • Interleukin-6
  • Microinflammation
  • Pentraxin-3
  • Vascular calcification

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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