Changes in cerebral blood flow accompanied with reduction of blood pressure treatment in patients with hypertensive intracerebral hemorrhages

Kiyoshi Kuroda, Noriyuki Kuwata, Naoya Sato, Masayuki Funayama, Akinori Yabuta, Souichi Taguchi, Michiyasu Suzuki, Akira Takahashi, Akira Ogawa

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Blood pressure usually is reduced in patients with hypertensive intracerebral hemorrhage for the prevention of the expansion of the hematoma and recurrent hemorrhage in acute stage. However, disturbed autoregulation of cerebral circulation is expected, and decreased cerebral blood flow (CBF) caused by excessive hypotension has been pointed out. There are different mechanisms of action in hypotensives, thereby the influence of hypotension on CBF in patients with the thalamic hemorrhage was investigated using nitroglycerin (TNG), diltiazem hydrochloride (DH) and trimethaphan camsilate (TC). Average CBF in a hemisphere on the hematoma side, the hemisphere without hematoma, and around the hematoma showed a slight decline after administration of TNG or DH. However, CBF declined more, after TC than DH. DH and TNG are preferable in descending order to control blood pressure of patients with intracerebral hemorrhage in the acute stages in view of a smaller decline in CBF.

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalNeurological research
Volume19
Issue number2
DOIs
Publication statusPublished - 1997 Jan 1

Keywords

  • CBF
  • Hypertensive intracerebral hemorrhage
  • autoregulation
  • hypotensives

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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