TY - JOUR
T1 - Changes in cerebral blood flow accompanied with reduction of blood pressure treatment in patients with hypertensive intracerebral hemorrhages
AU - Kuroda, Kiyoshi
AU - Kuwata, Noriyuki
AU - Sato, Naoya
AU - Funayama, Masayuki
AU - Yabuta, Akinori
AU - Taguchi, Souichi
AU - Suzuki, Michiyasu
AU - Takahashi, Akira
AU - Ogawa, Akira
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Blood pressure usually is reduced in patients with hypertensive intracerebral hemorrhage for the prevention of the expansion of the hematoma and recurrent hemorrhage in acute stage. However, disturbed autoregulation of cerebral circulation is expected, and decreased cerebral blood flow (CBF) caused by excessive hypotension has been pointed out. There are different mechanisms of action in hypotensives, thereby the influence of hypotension on CBF in patients with the thalamic hemorrhage was investigated using nitroglycerin (TNG), diltiazem hydrochloride (DH) and trimethaphan camsilate (TC). Average CBF in a hemisphere on the hematoma side, the hemisphere without hematoma, and around the hematoma showed a slight decline after administration of TNG or DH. However, CBF declined more, after TC than DH. DH and TNG are preferable in descending order to control blood pressure of patients with intracerebral hemorrhage in the acute stages in view of a smaller decline in CBF.
AB - Blood pressure usually is reduced in patients with hypertensive intracerebral hemorrhage for the prevention of the expansion of the hematoma and recurrent hemorrhage in acute stage. However, disturbed autoregulation of cerebral circulation is expected, and decreased cerebral blood flow (CBF) caused by excessive hypotension has been pointed out. There are different mechanisms of action in hypotensives, thereby the influence of hypotension on CBF in patients with the thalamic hemorrhage was investigated using nitroglycerin (TNG), diltiazem hydrochloride (DH) and trimethaphan camsilate (TC). Average CBF in a hemisphere on the hematoma side, the hemisphere without hematoma, and around the hematoma showed a slight decline after administration of TNG or DH. However, CBF declined more, after TC than DH. DH and TNG are preferable in descending order to control blood pressure of patients with intracerebral hemorrhage in the acute stages in view of a smaller decline in CBF.
KW - CBF
KW - Hypertensive intracerebral hemorrhage
KW - autoregulation
KW - hypotensives
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U2 - 10.1080/01616412.1997.11740792
DO - 10.1080/01616412.1997.11740792
M3 - Article
C2 - 9175147
AN - SCOPUS:0030973699
VL - 19
SP - 169
EP - 173
JO - Neurological Research
JF - Neurological Research
SN - 0161-6412
IS - 2
ER -