Changes in Ca2+/calmodulin-dependent protein kinase II activity and its relation to performance in passive avoidance response and long-term potentiation formation in mice prenatally exposed to diethylstilbestrol

T. Kaitsuka, K. Fukunaga, F. Soeda, T. Shirasaki, E. Miyamoto, K. Takahama

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16 Citations (Scopus)

Abstract

We investigated the effects of prenatal exposure to diethylstilbestrol (DES), an endocrine disrupter on learning behavior and synaptic functions. Specifically, we determined the activity of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and related kinases that play an essential role in long-term potentiation (LTP) in the hippocampus in mice that were prenatally exposed to DES. Treatment with DES resulted in increased CaMKII autophosphorylation and Ca2+-independent activity in the hippocampus and cortex of male mice. Impaired passive avoidance correlated with this increased CaMKII autophosphorylation, as did the enhanced early phase of LTP (E-LTP) in hippocampus. These data suggest that prenatal exposure to DES induces deficits in passive avoidance responses as a result of increased CaMKII activity and hippocampal LTP.

Original languageEnglish
Pages (from-to)1415-1424
Number of pages10
JournalNeuroscience
Volume144
Issue number4
DOIs
Publication statusPublished - 2007 Feb 23

Keywords

  • CaMKII
  • LTP
  • diethylstilbestrol
  • environmental endocrine disrupters
  • passive avoidance response
  • prenatal exposure

ASJC Scopus subject areas

  • Neuroscience(all)

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