Changes in bone mineral density after orchidectomy and hormone replacement therapy in individuals with androgen insensitivity syndrome

Hideki Mizunuma, Masayuki Soda, Hiroya Okano, Issei Kagami, Sumitaka Miyamoto, Minoru Ohsawa, Yoshito Ibuki

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Changes in bone mineral density (BMD) after orchidectomy and after hormone replacement therapy were reported in two patients with complete androgen insensitivity syndrome (AIS). Diagnosis of AIS was made by clinical features and confirmed by the presence of 46,XY karyotype and the presence of testis component in the removed gonads. BMD at the lumbar spine and at three sites of the femur was measured by dual energy X-ray absorptiometry (DXA). The Z scores of the lumbar spine BMD before orchidectomy were -0.8 and -3.1, confirming that patients with AIS have low BMD and that androgen plays an important role in bone mineralization in 46,XY individuals. Castration reduced BMD, but treatment with daily doses of 1.25 mg of conjugated oestrogen and 10 mg of medroxyprogesterone acetate increased BMD. These results indicate that both oestrogen and androgen play an important role in balancing BMD in men.

Original languageEnglish
Pages (from-to)2816-2818
Number of pages3
JournalHuman Reproduction
Volume13
Issue number10
DOIs
Publication statusPublished - 1998
Externally publishedYes

Keywords

  • Androgen insensitivity syndrome
  • BMD
  • Oestrogen
  • Testicular feminization
  • Testosterone

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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