TY - JOUR
T1 - Changes in backscatter of liver tissue due to thermal coagulation induced by focused ultrasound
AU - Shishitani, Takashi
AU - Matsuzawa, Ryo
AU - Yoshizawa, Shin
AU - Umemura, Shin Ichiro
N1 - Funding Information:
The presented work is partly supported by Tohoku University Global COE Program “Global Nano-Biomedical Engineering Education and Research Network Centre”, MEXT, Japan.
PY - 2013/8
Y1 - 2013/8
N2 - Ultrasonic imaging has advantages in its self-consistency in guiding and monitoring ultrasonic treatment such as high-intensity focused ultrasound (HIFU) treatment. Changes in ultrasonic backscatter of tissues due to HIFU treatment have been observed, but their mechanism is still under discussion. In this paper, ultrasonic backscatter of excised and degassed porcine liver tissue was observed before and after HIFU exposure using a diagnostic scanner, and its acoustic impedance was mapped using an ultrasonic microscope. The histology of its pathological specimen was also observed using an optical microscope. The observed decrease in backscatter intensity due to HIFU exposure was consistent with a spatial Fourier analysis of the histology, which also showed changes due to the exposure. The observed increase in acoustic impedance due to the exposure was also consistent with the histological change assuming that the increase was primarily caused by the increase in the concentration of hepatic cells.
AB - Ultrasonic imaging has advantages in its self-consistency in guiding and monitoring ultrasonic treatment such as high-intensity focused ultrasound (HIFU) treatment. Changes in ultrasonic backscatter of tissues due to HIFU treatment have been observed, but their mechanism is still under discussion. In this paper, ultrasonic backscatter of excised and degassed porcine liver tissue was observed before and after HIFU exposure using a diagnostic scanner, and its acoustic impedance was mapped using an ultrasonic microscope. The histology of its pathological specimen was also observed using an optical microscope. The observed decrease in backscatter intensity due to HIFU exposure was consistent with a spatial Fourier analysis of the histology, which also showed changes due to the exposure. The observed increase in acoustic impedance due to the exposure was also consistent with the histological change assuming that the increase was primarily caused by the increase in the concentration of hepatic cells.
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U2 - 10.1121/1.4813104
DO - 10.1121/1.4813104
M3 - Article
C2 - 23927213
AN - SCOPUS:84882385013
VL - 134
SP - 1724
EP - 1730
JO - Journal of the Acoustical Society of America
JF - Journal of the Acoustical Society of America
SN - 0001-4966
IS - 2
ER -