Changes in backscatter of liver tissue due to thermal coagulation induced by focused ultrasound

Takashi Shishitani, Ryo Matsuzawa, Shin Yoshizawa, Shin Ichiro Umemura

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Ultrasonic imaging has advantages in its self-consistency in guiding and monitoring ultrasonic treatment such as high-intensity focused ultrasound (HIFU) treatment. Changes in ultrasonic backscatter of tissues due to HIFU treatment have been observed, but their mechanism is still under discussion. In this paper, ultrasonic backscatter of excised and degassed porcine liver tissue was observed before and after HIFU exposure using a diagnostic scanner, and its acoustic impedance was mapped using an ultrasonic microscope. The histology of its pathological specimen was also observed using an optical microscope. The observed decrease in backscatter intensity due to HIFU exposure was consistent with a spatial Fourier analysis of the histology, which also showed changes due to the exposure. The observed increase in acoustic impedance due to the exposure was also consistent with the histological change assuming that the increase was primarily caused by the increase in the concentration of hepatic cells.

Original languageEnglish
Pages (from-to)1724-1730
Number of pages7
JournalJournal of the Acoustical Society of America
Issue number2
Publication statusPublished - 2013 Aug

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Acoustics and Ultrasonics


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