Change in Relative Mobility of M Protein Following Neuraminidase Treatment in Patients with Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance

Yuriko Kurihara, Shiro Iijima, Kouhei Fukushima, Toshiaki Hosaka, Kiyoko Shiba

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to clarify the relationship between the relative mobility of M protein in various disease states using cellulose acetate membrane electrophoresis. To examine the carbohydrate chain of the M protein, sera from patients with multiple myeloma (MM), various cancers, and benign disease were treated with neuraminidase. The relative mobility in benign disease and MM patient sera following neuraminidase treatment varied among individuals, while that of IgG M protein in sera from cancer patients was from 0.2 to 0.3. Thus, the relative mobility in cancer patients was narrower than in those with MM or benign disease. However, after neuraminidase treatment, there was no significant difference between relative mobility in cancer patient's sera and those in other disease patients.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalJournal of Clinical Laboratory Analysis
Volume18
Issue number3
DOIs
Publication statusPublished - 2004
Externally publishedYes

Keywords

  • Cellulose acetate membrane electrophoresis
  • M protein
  • Neuraminidase treatment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Clinical Biochemistry
  • Medical Laboratory Technology
  • Biochemistry, medical
  • Microbiology (medical)

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