Change in material and structural parameters of bone mechanical function during long-bone regeneration

Takuya Ishimoto, Takayoshi Nakano, Yukichi Umakoshi, Masaya Yamamoto, Yasuhiko Tabata

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Bone mechanical function is given as a result of the material and structural parameters of bone tissue. We previously reported that the material parameter of regenerated bone can be evaluated dominantly using two indices of the density and the preferred orientation degree of biological apatite (BAp). In addition, bone morphology remarkably changes during bone regeneration, which may lead to a dynamic change in the mechanical function of whole bone. In this study, therefore, material and structural parameters of regenerated bone are analyzed separately. A 5-mm-long defect was introduced in rabbit ulna and spontaneously regenerated, and then a three-point bending test was conducted at the regenerated portion. The important parameter which dominantly controls the whole bone mechanical function shifts from a structural to material parameter during bone regeneration. Moreover, it was statistically demonstrated that the increase in the material parameter is strongly determined by recovery of the orientation degree of the BAp c-axis.

Original languageEnglish
Title of host publicationSelected, peer reviewed papers from The Sixth Pacific Rim International Conference on Advanced Materials and Processing, PRICM 6
PublisherTrans Tech Publications Ltd
Pages1451-1454
Number of pages4
EditionPART 2
ISBN (Print)0878494626, 9780878494620
DOIs
Publication statusPublished - 2007 Jan 1
Event6th Pacific Rim International Conference on Advanced Materials and Processing, PRICM 6 - Jeju, Korea, Republic of
Duration: 2007 Nov 52007 Nov 9

Publication series

NameMaterials Science Forum
NumberPART 2
Volume561-565
ISSN (Print)0255-5476
ISSN (Electronic)1662-9752

Other

Other6th Pacific Rim International Conference on Advanced Materials and Processing, PRICM 6
CountryKorea, Republic of
CityJeju
Period07/11/507/11/9

Keywords

  • Biological apatite (BAp)
  • Bone regeneration
  • Microbeam X-ray diffraction (μXRD)
  • Section modulus
  • Three-point bending test
  • Ultimate load
  • Ultimate stress

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Ishimoto, T., Nakano, T., Umakoshi, Y., Yamamoto, M., & Tabata, Y. (2007). Change in material and structural parameters of bone mechanical function during long-bone regeneration. In Selected, peer reviewed papers from The Sixth Pacific Rim International Conference on Advanced Materials and Processing, PRICM 6 (PART 2 ed., pp. 1451-1454). (Materials Science Forum; Vol. 561-565, No. PART 2). Trans Tech Publications Ltd. https://doi.org/10.4028/0-87849-462-6.1451