Change in elasticity caused by flow-mediated dilation measured only for intima-media region of brachial artery

Masataka Sugimoto, Hideyuki Hasegawa, Hiroshi Kanai

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Endothelial dysfunction is considered to be an initial step of arteriosclerosis [R. Ross: N. Engl. J. Med. 340 (2004) 115]. For the assessment of the endothelium function, brachial artery flow-mediated dilation (FMD) caused by increased blood flow has been evaluated with ultrasonic diagnostic equipment. In the case of conventional methods, the change in artery diameter caused by FMD is measured [M. Hashimoto et al.: Circulation 92 (1995) 3431]. Although the arterial wall has a layered structure (intima, media, and adventitia), such a structure is not taken into account in conventional methods because the change in diameter depends on the characteristic of the entire wall. However, smooth muscle present only in the media contributes to FMD, whereas the collagen-rich hard adventitia does not contribute. In this study, we measure the change in elasticity of only the intima-media region including smooth muscle using the phased tracking method [H. Kanai et al.: IEEE Trans. Ultrason. Ferroelectr. Freq. Control 43 (1996) 791]. From the change in elasticity, FMD measured only for the intima-media region by our proposed method was found to be more sensitive than that measured for the entire wall by the conventional method.

Original languageEnglish
Pages (from-to)6297-6301
Number of pages5
JournalJapanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
Issue number8
Publication statusPublished - 2005 Aug 5


  • Atherosclerosis
  • Endothelium function
  • Flow-mediated dilation (FMD)
  • Nitric oxide (NO)

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)


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