Challenges for the synthesis of azadirachtin

Naoki Mori

doi:10.5059/yukigoseikyokaishi.76.506

Challenges for the synthesis of azadirachtin

Research output: Contribution to journal › Article › peer-review

Abstract

Azadirachtin is a complex natural product, which possesses sixteen contiguous stereogenic centers as well as various oxygen-containing functional groups. Completing the synthesis of this compound is one of the greatest challenges for synthetic chemists. It took about twenty-six years for us to achieve the second synthesis of azadirachtin in the world. In this article, I wish to describe the details of our synthetic studies on azadirachtin.

Original language	English
Pages (from-to)	506-509
Number of pages	4
Journal	Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume	76
Issue number	5
DOIs	https://doi.org/10.5059/yukigoseikyokaishi.76.506
Publication status	Published - 2018 Jan 1
Externally published	Yes

Keywords

Azadirachtin
Insect antifeedant
Natural products
Radical cyclization
Total synthesis

ASJC Scopus subject areas

Organic Chemistry

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10.5059/yukigoseikyokaishi.76.506

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AB - Azadirachtin is a complex natural product, which possesses sixteen contiguous stereogenic centers as well as various oxygen-containing functional groups. Completing the synthesis of this compound is one of the greatest challenges for synthetic chemists. It took about twenty-six years for us to achieve the second synthesis of azadirachtin in the world. In this article, I wish to describe the details of our synthetic studies on azadirachtin.

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KW - Total synthesis

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Challenges for the synthesis of azadirachtin

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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