Challenges for the synthesis of azadirachtin

Research output: Contribution to journalArticlepeer-review

Abstract

Azadirachtin is a complex natural product, which possesses sixteen contiguous stereogenic centers as well as various oxygen-containing functional groups. Completing the synthesis of this compound is one of the greatest challenges for synthetic chemists. It took about twenty-six years for us to achieve the second synthesis of azadirachtin in the world. In this article, I wish to describe the details of our synthetic studies on azadirachtin.

Original languageEnglish
Pages (from-to)506-509
Number of pages4
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume76
Issue number5
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

Keywords

  • Azadirachtin
  • Insect antifeedant
  • Natural products
  • Radical cyclization
  • Total synthesis

ASJC Scopus subject areas

  • Organic Chemistry

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