Cerebrospinal fluid CXCL13 is a prognostic marker for aseptic meningitis

Juichi Fujimori, Ichiro Nakashima, Hiroshi Kuroda, Kazuo Fujihara, Masashi Aoki

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


In exceptional cases, patients with aseptic meningitis eventually develop aseptic meningoencephalitis. To find a candidate marker for the development of aseptic meningoencephalitis in adult patients diagnosed with aseptic meningitis, we compared 12 different cytokines/chemokines in cerebrospinal fluid (CSF) from 5 patients with aseptic meningoencephalitis, 8 patients with aseptic meningitis, and 8 patients with control disease. Only the CXCL13 concentration was significantly elevated in the CSF of the group with aseptic meningoencephalitis compared with the group with aseptic meningitis. Thus, CSF CXCL13 may be a useful marker for predicting the prognosis of aseptic meningitis.

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - 2014


  • Aseptic meningitis
  • Aseptic meningoencephalitis
  • CXCL13
  • Cerebrospinal fluid (CSF)
  • Chemokine
  • Cytokine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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