Cerebrospinal fluid aquaporin-4 antibody levels in neuromyelitis optica attacks

Sato Douglas Kazutoshi, Dagoberto Callegaro, Frederico M. De Haidar Jorge, Ichiro Nakashima, Shuhei Nishiyama, Toshiyuki Takahashi, Renata Faria Simm, Samira Luisa Apostolos-Pereira, Tatsuro Misu, Lawrence Steinman, Masashi Aoki, Kazuo Fujihara

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25 Citations (Scopus)


To elucidate immunopathogenetic roles of aquaporin-4 antibodies in the cerebrospinal fluid (CSF) of neuromyelitis optica spectrum disorders (NMOSD), we analyzed aquaporin-4 antibody titers, cellular and inflammatory markers in the CSF collected from 11 aquaporin-4 antibody seropositive patients. The CSF aquaporin-4 antibody levels during attacks (but not in sera) closely correlated with pleocytosis, inflammatory cytokines including interleukin-6 that can regulate antibody-producing plasmablasts, and glial fibrillary acidic protein levels in the CSF. The amount of aquaporin-4 antibodies present in the central nervous system may have therapeutic implications, as it is associated with astrocyte injury and inflammatory responses during NMOSD attacks.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalAnnals of Neurology
Issue number2
Publication statusPublished - 2014 Aug

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Douglas Kazutoshi, S., Callegaro, D., De Haidar Jorge, F. M., Nakashima, I., Nishiyama, S., Takahashi, T., Simm, R. F., Apostolos-Pereira, S. L., Misu, T., Steinman, L., Aoki, M., & Fujihara, K. (2014). Cerebrospinal fluid aquaporin-4 antibody levels in neuromyelitis optica attacks. Annals of Neurology, 76(2), 305-309. https://doi.org/10.1002/ana.24208