Cerebral hyperperfusion on arterial spin labeling MRI after reperfusion therapy is related to hemorrhagic transformation

Shuhei Okazaki, Hiroshi Yamagami, Takeshi Yoshimoto, Yoshiaki Morita, Haruko Yamamoto, Kazunori Toyoda, Masafumi Ihara

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Early detection of hemorrhagic transformation after reperfusion therapy is crucial in acute stroke treatment. Here, we evaluated the relationship between hemorrhagic transformation and post-reperfusion hyperperfusion using pulsed arterial spin labeling (ASL) perfusion MRI and 123I-iodoamphetamine single-photon emission-computed tomography. Patients who developed hemorrhagic transformation showed significantly higher cerebral blood flow in the affected lesion after thrombolysis and/or endovascular intervention. Focal hyperperfusion (ipsilateral to contralateral ratio >1.5) was associated with hemorrhagic transformation after reperfusion (odds ratio, 9.3; 95% confidence interval, 1.4–64.0). Our findings suggest that post-reperfusion hyperperfusion on ASL could represent a reliable marker of hemorrhagic transformation.

Original languageEnglish
Pages (from-to)3087-3090
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Volume37
Issue number9
DOIs
Publication statusPublished - 2017 Sep 1

Keywords

  • Arterial spin labeling
  • acute stroke
  • intracranial/intracerebral hemorrhage
  • reperfusion
  • thrombolysis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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