TY - JOUR
T1 - Cerebral circulation in aging
AU - Nagata, Ken
AU - Yamazaki, Takashi
AU - Takano, Daiki
AU - Maeda, Tetsuya
AU - Fujimaki, Yumi
AU - Nakase, Taizen
AU - Sato, Yuichi
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Cerebral circulation is known to be protected by the regulatory function against the hypoperfusion that will affect the cognitive function as a result of brain ischemia and energy failure. The regulatory function includes cerebrovascular autoregulation, chemical control, metabolic control, and neurogenic control, and those compensatory mechanisms can be influenced by hypertension, atherosclerosis, cardiac diseases, cerebrovascular diseases and aging. On the other hand, large and/or small infarction, intracranial hemorrhage, subarachnoid hemorrhage, atherosclerosis, amylod angiopathy are also more directly associated with cognitive decline not only in those with vascular cognitive impairment or vascular dementia but also those with Alzheimer's disease.
AB - Cerebral circulation is known to be protected by the regulatory function against the hypoperfusion that will affect the cognitive function as a result of brain ischemia and energy failure. The regulatory function includes cerebrovascular autoregulation, chemical control, metabolic control, and neurogenic control, and those compensatory mechanisms can be influenced by hypertension, atherosclerosis, cardiac diseases, cerebrovascular diseases and aging. On the other hand, large and/or small infarction, intracranial hemorrhage, subarachnoid hemorrhage, atherosclerosis, amylod angiopathy are also more directly associated with cognitive decline not only in those with vascular cognitive impairment or vascular dementia but also those with Alzheimer's disease.
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U2 - 10.1016/j.arr.2016.06.001
DO - 10.1016/j.arr.2016.06.001
M3 - Review article
C2 - 27484894
AN - SCOPUS:84991051963
VL - 30
SP - 49
EP - 60
JO - Ageing Research Reviews
JF - Ageing Research Reviews
SN - 1568-1637
ER -