Cerebral circulation in aging

Ken Nagata; Takashi Yamazaki; Daiki Takano; Tetsuya Maeda; Yumi Fujimaki; Taizen Nakase; Yuichi Sato

doi:10.1016/j.arr.2016.06.001

Cerebral circulation in aging

Ken Nagata, Takashi Yamazaki, Daiki Takano, Tetsuya Maeda, Yumi Fujimaki, Taizen Nakase, Yuichi Sato

Research output: Contribution to journal › Review article › peer-review

35 Citations (Scopus)

Abstract

Cerebral circulation is known to be protected by the regulatory function against the hypoperfusion that will affect the cognitive function as a result of brain ischemia and energy failure. The regulatory function includes cerebrovascular autoregulation, chemical control, metabolic control, and neurogenic control, and those compensatory mechanisms can be influenced by hypertension, atherosclerosis, cardiac diseases, cerebrovascular diseases and aging. On the other hand, large and/or small infarction, intracranial hemorrhage, subarachnoid hemorrhage, atherosclerosis, amylod angiopathy are also more directly associated with cognitive decline not only in those with vascular cognitive impairment or vascular dementia but also those with Alzheimer's disease.

Original language	English
Pages (from-to)	49-60
Number of pages	12
Journal	Ageing Research Reviews
Volume	30
DOIs	https://doi.org/10.1016/j.arr.2016.06.001
Publication status	Published - 2016 Sep 1
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Biochemistry
Ageing
Molecular Biology
Neurology

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10.1016/j.arr.2016.06.001

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title = "Cerebral circulation in aging",

abstract = "Cerebral circulation is known to be protected by the regulatory function against the hypoperfusion that will affect the cognitive function as a result of brain ischemia and energy failure. The regulatory function includes cerebrovascular autoregulation, chemical control, metabolic control, and neurogenic control, and those compensatory mechanisms can be influenced by hypertension, atherosclerosis, cardiac diseases, cerebrovascular diseases and aging. On the other hand, large and/or small infarction, intracranial hemorrhage, subarachnoid hemorrhage, atherosclerosis, amylod angiopathy are also more directly associated with cognitive decline not only in those with vascular cognitive impairment or vascular dementia but also those with Alzheimer's disease.",

author = "Ken Nagata and Takashi Yamazaki and Daiki Takano and Tetsuya Maeda and Yumi Fujimaki and Taizen Nakase and Yuichi Sato",

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AU - Nagata, Ken

AU - Yamazaki, Takashi

AU - Takano, Daiki

AU - Maeda, Tetsuya

AU - Fujimaki, Yumi

AU - Nakase, Taizen

AU - Sato, Yuichi

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Cerebral circulation is known to be protected by the regulatory function against the hypoperfusion that will affect the cognitive function as a result of brain ischemia and energy failure. The regulatory function includes cerebrovascular autoregulation, chemical control, metabolic control, and neurogenic control, and those compensatory mechanisms can be influenced by hypertension, atherosclerosis, cardiac diseases, cerebrovascular diseases and aging. On the other hand, large and/or small infarction, intracranial hemorrhage, subarachnoid hemorrhage, atherosclerosis, amylod angiopathy are also more directly associated with cognitive decline not only in those with vascular cognitive impairment or vascular dementia but also those with Alzheimer's disease.

AB - Cerebral circulation is known to be protected by the regulatory function against the hypoperfusion that will affect the cognitive function as a result of brain ischemia and energy failure. The regulatory function includes cerebrovascular autoregulation, chemical control, metabolic control, and neurogenic control, and those compensatory mechanisms can be influenced by hypertension, atherosclerosis, cardiac diseases, cerebrovascular diseases and aging. On the other hand, large and/or small infarction, intracranial hemorrhage, subarachnoid hemorrhage, atherosclerosis, amylod angiopathy are also more directly associated with cognitive decline not only in those with vascular cognitive impairment or vascular dementia but also those with Alzheimer's disease.

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Cerebral circulation in aging

Abstract

ASJC Scopus subject areas

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