Cerebral blood flow and oxygen metabolism in infants with hydrocephalus

Reizo Shirane, Shinya Sato, Kiyotaka Sato, Motonobu Kameyama, Akira Ogawa, Takashi Yoshimoto, Jun Hatazawa, Masatoshi Ito

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

In this study, regional cerebral blood flow (rCBF) and the cerebral metabolic rate of oxygen (rCMRO2) were measured using positron emission tomography (PET) with oxygen-15 radiopharmaceuticals to clarify the pathophysiology of ventriculomegaly in the developing brain. Four hydrocephalic infants without severe neurological deficit were studied. Hypoperfusion was observed in the frontal, parietal, and visual association cortices which surrounded dilated anterior or posterior horns of the lateral ventricle. Lower rCMRO2 values than adult rates were observed in all cases. In the infants with markedly enlarged anterior or posterior horns, the surrounding cortices showed relatively lower rCMRO2 values with the fall of rCBF. Postoperative studies were performed in two infants. rCMRO2 increased in every region after ventriculoperitoneal shunting, but little change was observed in rCBF. These results indicate that metabolic deterioration occurs in the developing brain with hydrocephalus.

Original languageEnglish
Pages (from-to)118-123
Number of pages6
JournalChild's Nervous System
Volume8
Issue number3
DOIs
Publication statusPublished - 1992 May

Keywords

  • Cerebral blood flow
  • Infant
  • Oxygen metabolism
  • PET
  • hydrocephalus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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